College Football Schedule and Odds Highlight Promising Matchups
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College football is finally here, and the Week 0 college football schedule includes a handful of high-profile matchups that will interest college football bettors. The TCU Horned Frogs will take on the North Carolina Tar Heels at noon ET in Dublin, Ireland, on Saturday, and the latest Week 0 college football odds list TCU as the 7.5-point favorite, while the over/under is 47.5 points. You can also count Virginia vs. NC State (+4, 52.5) and Stanford vs. Hawaii (+4, 48.5) among the notable Week 0 college football matchups.
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The model simulates every FBS game 10,000 times. It is on a 31-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal to help nail college football betting picks at sportsbooks and on betting sites.
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The Wolfpack have dominated this rivalry in recent years, winning four consecutive meetings and six of the last seven overall. However, Virginia is coming off a record year, setting a school record 11 wins last season. The Cavaliers have won eight of their last nine season openers, while NC State has lost each of its past four games on the road.
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Bleacher ReportNC State (+5.5) at Virginia 3 of 5 What a year for Virginia it was. The Cavaliers lost only three football games last season, and the three losses came by a combined 18 points.
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So what college football picks can you make with confidence, and which underdog pulls off a shocking upset? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that is on a 31-19 run, and find out.
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Sacramento State at Eastern Michigan (-9.5, 52.5) New Mexico State at Florida State (-32.5, 53.5) Hawaii at Stanford (-3.5, 48.5) Memphis at UNLV (-4.5, 56.5)
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Independent claims that didn't surface elsewhere in our corpus. Treat as supplementary — not corroborated across outlets.
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01 CBS Sports All of the updated Week 0 college football prediction market prices are listed below, and SportsLine's advanced computer model has all the college football trading advice and CFB predictions you need to make the best Week 0 college football trades now. Claim the newest Kalshi promo code CBSSPORTS, trade $25, and get $25 in trading bonus credits:
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02 Bleacher Report Oh, it's been a journey. To arrive here, at actual football games, we've had to endure another dreadful offseason. From courtrooms to NIL drama to College Football Playoff expansion rumors, we've crawled through the mess that is the college football offseason.
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Sources (3)
- cbssports
- bleacherreport
- foxsports